Euflexxa vs. Synvisc: Which One Is Best?
- Medical Community Member - April 1st 2018
- General Public
Synvisc (hylan G-F 20) is the brand name for the high-molecular-weight injectable fluid that contains both hylan A and hylan B polymers. The polymers in Synvisc, like most hyaluronic derivatives, are derived from rooster combs and are classified as avian-derived hyaluronic acid (AV-HA).
Euflexxa, on the other hand is made from a very highly purified product extracted from bacterial cells. It is a polysaccharide consisting of a repeating disaccharide of N-Acetylglucosamine and sodium glucuronate that are linked by glycosidic bonds.
While Supartz, Synvisc, and other AV-HA brands are similar in their efficacy, Synvisc offers a one-dose treatment that prevents multiple trips to a doctor’s office. According to the National Institute of Health, AV-HA treatments all appear to relieve pain for between 4 and 14 weeks by restoring both mechanical and biomechanical homeostasis in the joint.
A difference in price gives Euflexxa a bit of an edge. At present, Euflexxa is about 20% cheaper than AV-HA treatments. However, in a free-market economy, the price difference between Euflexxa and AV-HA treatments is likely to switch repeatedly. But both treatments are still much cheaper than a total knee replacement, which can cost over $20,000 in the United States.
About Hyaluronic Derivative Treatments for Osteoarthritic Joints
Hyaluronic derivatives, called antirheumatics, are used for treating osteoarthritis and other joint conditions in which the body’s natural lubricant no longer functions as an adequate shock absorber—this is most notable in the arthritic knee. These pharmaceuticals are used when other measures fail. They are viscous substances that are injected into an osteoarthritic joint. This viscosupplementation helps to lubricate the joint, thereby diminishing friction, inflammation, and the resulting pain. The real benefit of this treatment is to delay— or even prevent—total knee replacement. This is especially important because artificial knees have a short life span, so a young knee-replacement recipient would be likely to require a second replacement.
The Importance of Sodium Hyaluronate
Sodium hyaluronate is a natural and common polysaccharide that is found in both connective tissue and synovial fluid. The lubricative properties in the synovial fluid are important to the smooth functioning of a joint. Because it is both viscous and elastic, sodium hyaluronate injections can help supplement joint lubrication when the natural processes fall short. Most hyaluronic derivatives come from rooster combs. One hyaluronic derivative in particular— Euflexxa— is different in that it is produced commercially from bacterial cells. Thus, Euflexxa is the first non-avian-derived hyaluronic derivative.
Considerations for Choosing a Treatment
Typically, the choice of which drug to prescribe is based on a risk-vs-benefit scale. Cost-effectiveness also comes into play when third-party payers implement cost-containment measures. Sometimes the cost of these treatments can be misleading. For example, the cost of the single dose Synvisc-One is about three times higher than the cost of the same treatment given in three weekly doses. Therefore, the only savings would come from fewer co-pays resulting from fewer office visits.
However, the scientific literature on various joint treatments also incorporates a very important factor into the cost: the delay in total knee replacement that can be achieved. The longer the delay, the more the cost savings. It is on this measure that Euflexxia seems to score slightly higher than other hyaluronic derivatives.
Disclaimer: The contents of this article are not to be constructed as medical advise but for informational purposes only. MedicaDepot staff does not review any of this articles for medical validity. Opinions and views expressed in this article are not endorsed by MedicaDepot. Please always consult your doctor for professional medical advise.