Synvisc is a treatment for osteoarthritis (OA) pain of the knee in patients who have failed to find relief by conservative nonpharmalogic therapy and simple analgesics (example: acetaminophen). Synvisc was developed and is manufactured by the Genzyme Corporation. Synvisc provides lubrication to the knee and acts as a "shock absorber" for the knee joint. Synvisc is simalar to synovial fluid that is found naturally in the joints and is made from a substance called hyaluronan that is found in normal joint fluid.
It is shown that Synvisc is effective in all stages of Osteoarthritis, although most effective in less severe stages of this disease.
Uses:

• Synvisc is used to relieve pain in the knee due to OA (osteoarthritis). This product is used when other forms of pain relievers do not provide enough relief. This medication is only for injection into the knee, and should only be performed by a doctor. The doctor will inject 2ml into the knee once a week, for a total of 3 weeks. Results don't always appear within the first week of treatment, it can take from 8 to 12 weeks after the start of treatment.

Precautions:

• Avoid strenuous activity or prolonged (longer then an hour) weight-bearing activity (jogging, running, strenuous sport, lifting weights) for 48 hours following an injection of Synvisc unless you are otherwise directed by your doctor. Remember to keep Synvisc and all other medicines out of the reach of children. Never share your medications with others, and use Synvisc only as prescribed. This has not been tested in children, pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child. Synvisc should not be used if there is an infection or skin disease at the site of injection.

• An overdose of Synvisc is unlikely to threaten your life. Even so, if an overdose of Synvisc does occur or is suspected contact your doctor and seek immediate medical attention.

Do NOT use Buy Synvisc Solution if:

• you are allergic to any ingredient in Synvisc Buy Solution

•  you have an infection where Synvisc Buy Solution will be injected

• Contact your doctor or health care provider right away if any of these apply to you.

Before using Buy Synvisc Solution:

Some medical conditions may interact with Synvisc Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

•  if you are pregnant, planning to become pregnant, or are breast-feeding

• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

•  if you have allergies to medicines, foods, or other substances

•  if you have a skin disease

•  if you have an allergy to bird proteins, feathers, or eggs

• if you have blood flow problems

• Some MEDICINES MAY INTERACT with Synvisc Solution. However, no specific interactions with Synvisc Solution are known at this time.

• This may not be a complete list of all interactions that may occur. Ask your health care provider if Synvisc Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Synvisc Solution:

• Use Synvisc Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Synvisc Solution comes with an additional patient leaflet. Read it carefully and reread it each time you get Synvisc Solution refilled.

• Buy Synvisc Solution is administered as an injection at your doctor's office, hospital, or clinic.

• Do not miss your doctor appointments while you are taking Synvisc Solution.

• If you must miss an appointment, notify your doctor as soon as possible.

• Do not miss your doctor appointments while you are taking Synvisc Solution.

• If you miss a dose of Synvisc Solution, contact your doctor right away.Ask your health care provider any questions you may have about how to use Synvisc Solution.

Important safety information about Synvisc Solution:

• It may take several injections for Synvisc Solution to work fully. Complete the full treatment course, even if you are already feeling better.

• Avoid strenuous activities or prolonged weight-bearing activities, such as jogging or tennis, after receiving an injection.

• Use Synvisc Solution with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.

• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Synvisc Solution during pregnancy. It is unknown if Synvisc Solution is excreted in breast milk. If you are or will be breast-feeding while you are using Synvisc Solution, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Synvisc Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

• Knee pain or swelling after injection.

Seek medical attention right away if any of these SEVERE side effects occur:

• Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); ankle swelling; bruising; calf cramping; fast heartbeat; fever; hemorrhoids; muscle pain; nausea; persistent pain, redness, or swelling at injection site; sweating.

• This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

Proper storage of Synvisc Solution:

• Synvisc Solution is usually handled and stored by a health care provider. Keep Synvisc Solution, as well as needles and syringes, out of the reach of children and away from pets. Buy, Buy, Buy, Buy.

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